It's the first time that we buy this product, my mother takes every day the Immune Assist Critical Care, Red Reishi, Bio-silymarin, Agaricus Blazei- Aloha Medicinals for 4 years now, with great results and this time we decided to give it a try with this one, 24/7 because I've read great reviews and we are absolutely sure that it will raise at the above mentioned product standards.