I use this on clean skin, before adding make up / moisturizer / SPF.
I find it works best by letting it soak in for 5+ minutes before adding anything on top. Their previous formula had probiotics, this one doesn't but they seem to work similarly. Keeps my skin much more even and toned.
If I am just staying home/inside, I will even just wear this with nothing on top.
Very nice for day and night.